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0:58
YouTube
MedLecturesMadeEasy
Metformin-associated lactic acidosis: pathophysiology and manifestations
Metformin helps restore body response to insulin: decrease hepatic glucose output decrease glu absorption in stomach and intestines increase glucose use in periphery Reduces pyruvate dehydrogenase activity + Reduces transport of mitochondrial reducing agents → increased anaerobic metabolism → pyruvate accumulates → pyruvate metabolized to ...
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