This study presents fundamental findings on the role of transcription readout and intron retention in transposon expression during aging in mammals. The evidence supporting the claims of the authors ...

Fraction of genic or intronic transposons and of transposons downstream (ds) or upstream (us) of genes in two different datasets. Fig. 1. A concerted increase in transposon and intron expression with ...

Introns are major components of eukaryotic genomes with poorly understood origins. Introners, transposable elements (TEs) which can generate introns upon insertion, are thought to be major drivers of ...

Human epidermal growth factor receptors (HER/ERBB) form dimers that promote cell proliferation, migration, and differentiation, but overexpression of HER proteins results in cancer. Consequently, ...

High tumor mutation burden (TMB) in many cancer types is associated with the production of tumor-specific neoantigens, a favorable outcome and response to immune checkpoint blockade (ICB) therapy.

I working on blood cancer sample, and there is a special fusion PML-RARA that usually have some intron insertion between exon. For example PML(exon2)-RARA(100bp intron2)-RARA(exon3). Some reads that ...

Diverse DNA structural variations (SVs) in human cancers and several other diseases are well documented. For genomic inversions in particular, the disease causing mechanism may not be clear, ...

What steps will reproduce the problem? 1. Run intersectBed -split -bed -wao -abam test.bam -b test.gtf with test.bam containing a spliced read (N in CIGAR) and test.gtf containing a feature (exon, etc ...

Finally, we confirmed efficient and specific binding between the DNA-oligonucleotides and D135–L14 by nondenaturing gel electrophoresis (Fig. S2). Taken together, the above results demonstrate that ...