This study presents a valuable tool named TSvelo, a computational framework for RNA velocity inference that models transcriptional regulation and gene-specific splicing. The evidence supporting the ...

With a new study in the journal Cell, researchers at Stanford University and Stockholm University have contributed to ...

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are expressed in ...

Gene expression analysis is undergoing a profound transformation, driven by the rapid evolution of advanced omics technologies. From single-cell ...

Researchers at The University of Texas MD Anderson Cancer Center have shown that DNA inflexibility, or rigidity, inside the nucleosome regulates the positioning of INO80. This highlights that the ...

EVE is a deep generative model combining evolutionary and human population data to estimate variant deleteriousness on a proteome-wide scale.

Single-cell genome sequencing techniques have recently emerged, enabling high-throughput transcriptome profiling at the level of individual cells. Among ...