Scientists have discovered a hitherto unknown function of blood platelets in cancer. In mouse models, these platelets have proved to help preserve the vascular barrier which makes blood-vessel walls ...

Patients on prasugrel therapy have greater platelet inhibition than those taking maintenance doses of clopidogrel and thus require a longer time to return to baseline reactivity after stopping the ...

Ado-trastuzumab emtansine (T-DM1) treatment results in grade 3-4 thrombocytopenia in 8%-13% of patients. Prior in vitro studies reported T-DM1 inhibition of megakaryocyte maturation as the cause of ...

"Platelets are the smallest blood cells that work in clotting to heal cuts because they stick to the site of the injury," said Xia, a member of OMRF's Cardiovascular Biology Research Program. "This ...

A new study successfully identifies new genetic variants involved in the formation of platelets and more importantly, defines how genes near these variants affect platelet size and number using a ...

Study of the bleeding tendency in uremia in 26 subjects, 10 of whom were bleeding, showed platelet counts and plasma coagulation factors to be normal. There was a significant inverse correlation ...

Randomized trials of platelet function and genetic testing to guide antiplatelet decisions following PCI have produced notoriously mixed results: now, an updated consensus document aims to fill some ...

Managing drug dosage is critical to the overall success of pharmaceutical intervention, not only in the clinic but also in clinical trials. Inadequate dose management of certain drugs can have fatal ...

While thrombocytopenia and bleeding are events that often occur together in neonates, this may not signify cause and effect. In fact, one study reported that 91% of neonates with low platelet counts ...

Mesenchymal stem cells are both a success story and underperformers. Globally, there are 10 approved MSC-based therapies in nearly as many indications, although none of them have been approved by the ...