The mechanism of action of NNRTIs is illustrated in Figure 1. Reverse transcriptase catalyzes RNA-dependent and DNA-dependent polymerase activities, which are essential for viral DNA synthesis when ...
HIV-1 reverse transcriptase inhibitors remain a cornerstone of antiretroviral therapy, targeting the enzyme responsible for converting viral RNA into DNA. This class of drugs, particularly nucleoside ...
Nonnucleoside Reverse-transcriptase Inhi... Nonnucleoside Reverse-transcriptase Inhibitor- vs Ritonavir-boosted Protease Inhibitor–based Regimens for Initial Treatment of HIV Infection: A Systematic ...
The anti-AIDS drug rilpivirine undergoes conformational changes to bind HIV-1 reverse transcriptase (RT), which is an essential enzyme for the replication of HIV. These changes allow it to retain ...
Infection with human immunodeficiency virus type 1 (HIV-1), the retrovirus that causes the acquired immunodeficiency syndrome (AIDS), is one of the leading causes of death worldwide. All currently ...
Partnership delivers advanced reverse transcriptase technology to enhance sensitivity, robustness and reproducibility of molecular analysis in clinical, applied and pharmaceutical applications Promega ...
Researchers show that polymerase theta can efficiently convert RNA sequences back into DNA, a feat more common in viruses than eukaryotic cells. Editor's Note: Thomas Jefferson University issued the ...
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