Cytoplasmic dynein is a microtubule motor involved in cargo transport, nuclear migration and cell division. Despite structural conservation of the dynein motor domain from yeast to higher eukaryotes, ...

During mitosis in budding yeast, dynein moves the mitotic spindle into the mother-bud neck. We have proposed an offloading model to explain how dynein works. Dynein is targeted to the dynamic plus end ...

Movement signals life, and nowhere is this truer than inside a living cell. The millions of proteins and molecules within each of our cells bend, travel and conform in a complex but orchestrated ...

In a cleverly designed experiment, cell biologists have discovered how dyneins organize chromosome placement to prepare for cell division. The surprise finding suggests it's the motor domain of the ...

What is the dynein-dynactin complex and where is it found? What functions is this molecular motor thought to perform within cells? This is a macromolecular assembly is made up of two components, ...

Harvard – Molecular motors, built from proteins, are a kind of transport service that keep cells functioning. They traffic essential chemical packages between the heart of the cell, the nucleus, and ...

CORVALLIS, Ore. (KTVZ) – Oregon State University scientists say they have taken a key step toward better understanding neurodegenerative diseases by using a suite of biophysical techniques to learn ...

Biologists have identified a new molecular player in asymmetric cell division, a regulatory protein named She1 whose role in chromosome- and spindle positioning wasn't known before. Asymmetric cell ...

Intracellular protein aggregation is a common theme in neurodegenerative disease. The formation of aggregates is blamed on protein overproduction, a failure of clearance, or both. Score one for the ...

Please can you give an overview of your research interests? In my lab, we focus on understanding structure, assembly and regulation of the LC8 protein interaction network, the array of LC8 ...

CORVALLIS, Ore. – Oregon State University scientists have taken a key step toward better understanding neurodegenerative diseases by using a suite of biophysical techniques to learn more about a motor ...