I have a patient with trigeminal neuralgia who was taking 1600 mg of gabapentin and had serious elevations of liver function tests (aspartate transaminase 258 U/L, alanine transaminase 296 U/L). This ...

During glycine oxidation by spinach leaf mitochondria, oxygen consumption showed a strong and transient inhibition upon addition of oxaloacetate or aspartate plus α-ketoglutarate. During the course of ...

The current guideline for diagnosis of ALD and AH is summarised here. AH, alcohol-associated hepatitis; ALD, alcohol-associated liver disease; ALT, alanine transaminase; AST, aspartate transaminase; ...

Only two months after Centessa dropped its lead asset due to a patient experiencing elevated liver enzymes, the biotech has now culled an early-stage candidate over a similar adverse event. Centessa ...

Alanine transaminase (ALT) 0-37 U/L 131 ± 96 U/L 2-10 × normal range Aspartate transaminase (AST) 0-40 U/L 119 ± 51 U/L 2-10 × normal range Alkaline phosphatase 30-117 U/L 146 ± 66 U/L Increases ...