Mitotic exit follows shortly after microtubule attachment of the last unattached kinetochore. Two new studies illustrate the molecular basis of this dependency. At metaphase, all sister chromatid ...
The spindle assembly checkpoint (SAC) prevents aneuploidy by coupling anaphase onset, through anaphase-promoting complex (APC) activation, with chromosome attachment to spindle microtubules. Here, we ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 4 (January 26, 2016), pp. 966-971 (6 pages) The mitotic (or spindle assembly) checkpoint system prevents ...
Rad52 is well known as a key factor in homologous recombination. Here, we report that Rad52 has functions unrelated to homologous recombination in Saccharomyces cerevisiae; it plays a role in the ...
The ADEBAR trial: Final toxicity analysis of a phase III study evaluating the role of docetaxel in the adjuvant therapy of breast cancer patients with extensive lymph node involvement No significant ...
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Figure 1: A light micrograph of a large oocyte in an ovary. RIKEN researchers have found that MPS1 promotes timely spindle bipolarization when oocytes in mice undergo ...
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