Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

For almost 60 years, scientists have tried to understand why DNA doesn't replicate wildly and uncontrollably every time a ...

DNA is often described as the instruction manual for building the fundamental components of life. Proteins are helpers that ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

Researchers have uncovered a microscopic weapon that can literally tear viruses apart from the inside, a single protein that turns a cell’s own DNA into a tripwire. Instead of blocking infection at ...

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown ...

Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature ...