DNA repair can be divided into a set of mechanisms that identify and correct damage in DNA molecules. There are two general classes of DNA repair; the direct reversal of the chemical process ...
Scientists have elucidated the first steps of transcription-coupled repair (TCR), a critical but still mysterious mechanism of DNA repair. When genetic information is being transcribed from DNA to RNA ...
The Philadelphia (Ph) chromosome resulting from reciprocal t(9;22) translocation was the first reported chromosomal rearrangement linked to a human malignancy. 1 The Ph chromosome results in BCR-ABL1 ...
Covalent DNA–protein crosslinks (DPCs) are highly toxic DNA lesions that are induced by widely used classes of chemotherapeutics and also by various external and endogenous agents. DPCs consist of ...
Researchers at the University of Toronto and partner hospitals have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy – a finding that could lead to new ...
A research team led by Professor ZHAO Guoping at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, has unveiled a crucial mechanism that helps regulate DNA damage repair, ...
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