Ribosomal engineering creates 'super-probiotic' bacteria with enhanced immune activation

Using ribosome engineering (RE), researchers from Shinshu University introduced mutations affecting the protein synthesis ...

A closer look at how local protein production is altered in ALS

The functioning of neurons, cells that transmit information in the nervous system, heavily relies on the production of ...

Axonal protein synthesis defect identified as potential early driver in ALS progression

Researchers at VIB and KU Leuven have identified a molecular process that allows motor neurons to maintain protein production ...

New mutations in TP53 gene drive resistance to p53-targeted cancer therapy

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for ...
News Medical

Researchers create first mouse model carrying a disease-associated mitochondrial mutation

Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models with the ...
Baylor College of Medicine

AI reveals how protein modifications link mutations to disease

Researchers at Baylor College of Medicine have developed an artificial intelligence (AI) model that reveals how protein modifications link genetic mutations to disease. The method, called DeepMVP and ...
Science Daily

First mouse model with mitochondrial tRNALeu mutation developed

Researchers have developed the first mouse model for a mitochondrial tRNALeu mutation, showing that the associated metabolic disorder results from faulty RNA processing. Studying the role of ...
Nanowerk

Transfer RNA (tRNA): The Adaptor Molecule in Protein Synthesis

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...