Investigators led by Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how the metabolism of mitochondria supports ...

T lymphocytes differentiate from naïve precursors upon antigen encounter into distinct effector and memory subsets. Following priming by antigen-presenting cells in lymphoid tissues, naïve CD4+ and ...

The Israeli study examined tumor samples and nearby lymph nodes from 11 patients with high-grade serous ovarian cancer.

We owe a lot to tissue resident memory T cells (T RM). These specialized immune cells are among the body's first responders to disease. Rather than coursing through the bloodstream-as many T cells ...

Memory T cells are a special type of white blood cell that "remember" past infections and vaccines, helping our bodies to quickly respond if we encounter the same germs again. These cells are found ...

Researchers have shown for the first time that malfunctioning mitochondria — the cell’s energy generators — may directly cause cognitive decline in neurodegenerative diseases. By creating a new tool ...

T-bet expression is required for persistence of memory B cells that have rapid differentiation potential to become antibody-producing plasma cells in response to a second infection BIRMINGHAM, Ala. – ...

However, details of the intervening steps, as researchers have learned in the past 65 years, are quite complex — certain cells carry the flu antigen to the immune system, specific immune cells respond ...