Scientists have discovered how a mitochondrial mutation rewires immune function in a model of inherited primary mitochondrial disorders, which often lead to severe disability and death. They have ...

Ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disease characterized by ectopic bone formation in the spine, leading to severe neurological symptoms due to spinal ...

A novel tumor suppressor, BATF2, can be silenced by factors in the tumor microenvironment, leading to a reduced immune ...

In the study, "MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists," published in Science, researchers designed a series of molecular and in vivo experiments to ...

Global trends and regional disparities in young-onset breast cancer: Age-specific patterns from 1990 to 2021.

BATF2 is a new type of tumor suppressor that can be epigenetically silenced by high levels of glutamine in the tumor microenvironment Glutamine silences BATF2 and leads to a weakened immune response ...

Duke Health researchers found a relationship between immune response and neurological behavior after studying mice with a specific gene mutation, which exhibited signs of ADHD in response to an ...

Intracellular Delivery via EV-based Approach (IDEA) was designed to efficiently package and deliver non-fused intracellular proteins to cytoplasmic or nuclear compartments to be functional. As a ...

More than 7 million Americans have Alzheimer's disease, and two-thirds of them are women, according to the Alzheimer's ...