These complement other leading models that were recently made available, including GREmLN, a graph-aware model for understanding how gene regulatory networks govern cell behavior, and rBio, a ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

Assembloids: A Versatile Platform for Human Tissue Modeling. This schematic illustrates the classification of assembloids based on four key assembly strategies—multi-region, multi-lineage, ...

Scientists are exploring ways to mimic the origins of human life without two fundamental components: sperm and egg. They are coaxing clusters of stem cells – programmable cells that can transform into ...

Human periportal assembloid, showcasing the three key cell types of the liver: portal fibroblasts (magenta), cholangiocytes (green), and hepatocyte nuclei (blue). All cell borders are delineated in ...

A fundamental challenge in preclinical research is accurately predicting human responses using conventional animal models. Traditional approaches often fail to adequately model human disease, creating ...

Traditional animal models and simplified cell cultures often fail to capture human biology, limiting progress in biomedical research and drug development. Emerging microfluidic "Organ-on-Chip" ...

Researchers recently developed a bone marrow model to study how the body generates cells. Interestingly, this model is the first of its kind to be developed entirely from human cells. Not only can ...

Our cells are continually being exposed to environmental assaults. For instance, skin is exposed to pollutants and UV radiation. Our lungs are subject to environmental stimuli such as smoke ...