Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

Researchers at The University of Tokyo developed TECHNO, a two-step genome editing strategy that replaces entire mouse loci ...

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes ...

Understanding how a potential drug is metabolised in the liver is a critical first step in early-stage drug development - but ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

Mice and newts were applied to the one-step Cre-loxP organism creation technology by TAx9. In this study, the researchers succeeded in synthesizing a Cre-loxP integrated vector by placing a short DNA ...

Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

What if you could flip a genetic switch to silence a gene, then turn it back on with a simple drug? For researchers, gene-switch tools offer that kind of control—and a new system called Cyclone may ...

Humanized mouse models are vital for studying human gene function, but fully replacing mouse genes with complete human ...