Aldosterone synthase (CYP11B2) is the key enzyme responsible for the final steps in aldosterone production, a steroid hormone that plays a critical role in the regulation of electrolyte balance and ...

As the cells differentiated, they expressed even higher levels of genes involved in aldosterone synthesis and became increasingly active. "The identification of two distinct cell fates in APAs ...

Current treatment options for primary aldosteronism are limited to surgery or mineralocorticoid receptor antagonists when surgery isn't an option. In a phase IIa trial, baxdrostat resolved or reduced ...

Angiotensin II and aldosterone are also involved in regulating inflammatory and reparative processes that follow tissue injury. 19,20 In this capacity, they stimulate cytokine production, inflammatory ...

Single-nucleus RNA sequencing of 2 nonfunctional adenomas and 3 aldosterone-producing adenomas revealed 13 clusters (Upper). Pseudotime course analysis predicted the transition of two cell fates in ...

Credit: Getty Images Investigators report promising results from a phase 2 trial of an investigational aldosterone synthase inhibitor. Combining the aldosterone synthase inhibitor with empagliflozin ...

What if there were a straightforward and relatively inexpensive way to lower the incidence of heart failure (HF), renal disease, stroke, and cognitive impairment? Cardiologist Bertram Pitt, MD, said ...

Lorundrostat treatment led to greater reductions in 24-hour mean blood pressure compared with placebo in trial participants with uncontrolled and treatment-resistant hypertension. Lorundrostat, a ...

Hypertension is an important public health problem affecting more than 50 million individuals in the US alone. The most common form, essential hypertension, results from the complex interplay between ...

MADRID -- For uncontrolled or treatment-resistant hypertension, adding the novel aldosterone synthase inhibitor baxdrostat improved blood pressure in the randomized BaxHTN trial. Seated systolic blood ...