It is increasingly recognized that common diseases are not consequences of independent actions of the genes, but are caused by complex joint actions of multiple genetic and environmental risk factors.

Evaluation of statistical interaction in time-to-event analysis is usually limited to the study of multiplicative interaction, via inclusion of a product term in a Cox proportional-hazard model.

In nonparametric multivariate regression analysis, we seek methods to reduce the dimensionality of the regression function to bypass the difficulty caused by the curse of dimensionality. The original ...